Restylane Refyne

Restoring a youthful appearance by treating lines, wrinkles and folds

Restylane Refyne can be used to provide natural-looking correction of lines, facial wrinkles and folds, such as lines from the nose to the corners of the mouth (nasolabial folds), between the eyebrows and on the forehead.  Find out more how Restylane Refyne can restore your youthful appearance and the different areas that can be treated.

Restylane Refyne is crafted with Optimal Balance Technology to restore a youthful appearance with long lasting results. Restylane Refyne is clinically proven to last up to 18 months, with just one retreatment. The unique cross-linking of the hyaluronic acid gel in Restylane Refyne is also designed with flexibility to help support your facial expressions – for natural looking results, while helping to maintain natural expressions in motion. More than 97% of candidates in clinical studies are satisfied with the results and would do the treatment again. 

Find out more about the full range of Restylane products and why they are the most suitable to address your unique needs and concerns.


Restylane Refyne is a hyaluronic acid gel that has been developed for the treatment of lines, facial wrinkles and folds. It produces natural-looking results for a fresh and youthful appearance that are long lasting with duration up to 18 months, with just one retreatment.

Restylane Refyne is designed with flexibility to help support your facial expressions – for natural looking results, while helping to maintain natural expressions in motion. More than 97% are satisfied with the results and would do the treatment again.

Treatments with Restylane Refyne offer a particularly high level of comfort due to the integrated local anaesthetic, lidocaine.

Lines, wrinkles and folds in the lower face

  • Nasolabial folds (from the nose to the corner of the mouth)
  • Oral Commissures (around the corner of the mouth)
  • Marionette lines (from the corner of the mouth to the chin)

Frown Lines

Do visible lines hide your true facial expression? Restylane Refyne will help you smooth out those unwanted lines and let the true you shine through.

Worry Lines

You don’t have to worry about your worry lines anymore! Restylane Refyne takes care of the problem and in just a few moments your worry lines are just a memory.

Crow’s Feet

Fine lines around your eyes can get on your nerves. There is a simple way to reduce their affect – with Restylane Refyne you can smooth those lines away – safely and naturally.

Eye area

Looking tired around the eyes? Your eyes are the center of attention when you communicate with others – and a gloomy look can give the impression that you are not as energetic as you feel, or would like to look.  A Restylane treatment of your eye brows, crow’s feet or tear trough (tired eyes) will bring that lively look back to your eyes.


Restylane, Restylane Refyne, Refyne Treatments
  1. Crow's feet (periobital lines)
  2. Tear trough (tired eyes)
  3.  Eye brow


Before After
Restylane, Restylane Refyne, Refyne Treatments, Brow Before Restylane, Restylane Refyne, Refyne Treatments, Brow After
Restylane, Restylane Refyne, Refyne Treatments, Worry Lines Before Restylane, Restylane Refyne, Refyne Treatments, Worry Lines After


Restylane, Restylane Refyne, Refyne Treatments, One month after treatment

42-year-old Birgitta was treated with Restylane Refyne, Restylane Fynesse and Restylane Volyme in her tear trough (eyes), glabella (forehead) and cheeks.



  • Be honest with yourself about your wishes and questions.
  • You will learn how Restylane products can be safely used to suit your wishes
  • You will be asked about your medical history.
  • Together with your physician you decide which Restylane product is suitable for your needs.
  • Before treatment, the practitioner will discuss pain relief with you.
  • Depending on which area you will have treated you will also have a choice of other anesthesia, such as anesthetic cream, dental block or ice.
  • A treatment with Restylane only takes about 15-30 minutes. It is performed by injecting Restylane through a fine needle into your skin (or for some treatments just under) to fill wrinkles or add volume, shape your face or lips or rejuvenate your skin.



  • After treatment you will receive post-treatment guidelines.
  • It is normal to experience some post-treatment discomfort, such as redness, swelling, pain, itching, bruising or tenderness at the treatment site.  This typically subsides after a few days, up to one to two weeks.
  • Following treatment, there is sometimes a need for a touch-up treatment to achieve an optimal result.



  • As Restylane is naturally biodegraded, you will eventually need to repeat the treatment to maintain the result. Return visits are typically made after 6-12 months for wrinkles and within 6 months for lips.
  • For skin rejuvenation with Restylane Skinboosters a typical treatment program is made up of three treatment sessions with 2-4 weeks apart and then repeat treatments approximately every 6 months.


Restylane Refyne is based on hyaluronic acid, a crystal clear gel that is injected into the skin (or for some treatments just under) in small amounts to restore volume and structure.


Hyaluronic acid (HA) is widely found throughout the body as well as in most other living organisms. It has many functions, from giving the skin elasticity to maintaining its fullness and binding large amounts of water.


Restylane Refyne is HA crafted with the Optimal Balance Technology (OBT). This technology offers a broad range of gel textures, all containing the same concentration of Hyaluronic Acid gels (HA), which means that the products can serve a wide range of functions. Softer gels distribute more evenly to smooth lines and wrinkles, and firmer gels can deliver more lift and volume.

The different gel textures are achieved by varying the number of connections, or ‘cross-links’ between HA molecules. Fewer cross-links between HA molecules give rise to a softer gel, whereas more cross-links between HA molecules result in a firmer gel The range of gel textures is combined with different sizes of gel particles to vary the product’s lifting capacity even further.

Optimal Balance Technology (OBT) creates a softer gel texture compared to NASHA Technology that distributes more evenly to create a softer look. HA gels with OBT have  demonstrated results that last up to 18 months with just one maintenance treatment (except Restylane Fynesse with a duration up to 6 months). OBT is used exclusively in the following Restylane products to achieve diverse effects depending on the treatment area:

  • Restylane VolymeTM, Restylane DefyneTM and Restylane KysseTM have a larger gel particle size to provide volume and add definition
  • Restylane FynesseTM and Restylane RefyneTM have a smaller gel particle size, offering a lower lifting capacity to target superficial wrinkles and fine lines

Speak to your doctor to discuss which Restylane product could help address your individual treatment needs.

OBT combines a varied number of contacts between HA molecules with differently sized gel particles to achieve different results



Josefine Age 30

Music and singing teacher

"I did this for me"

I was curious to see if a treatment could get rid of the worry wrinkles above my brow. No one has commented that they are gone, but I take that to be a good sign. It only matters that I see the difference.

I have never done any kind of aesthetic treatment before. When I squint I have these worry wrinkles above my brow and they seemed to linger there long after I’d stopped squinting. They make me look a little angry when I’m not. So I was curious to see if a treatment could get rid of that. It’s not that I’m really worried about what others think of me, I did it for myself.

My biggest concern with the treatment was that I absolutely did not want it to look like I had done something to my face. I didn’t want to alter the way I look. I was also afraid it would hurt and that it would be sore or red for a long time. But I don’t think it showed that much and it certainly did not hurt – probably because the clinician put an anaesthetic cream all over my face.

The treatment itself didn’t take that long, maybe a total of half an hour. I did have fairly big bumps on my forehead afterward, so I didn’t go into work the next day, but I went to work the day after that and no one noticed a thing.

In fact, no one has commented at all. But I take that to be a good sign, because I did this for me. It only matters that I see the difference. Not only are the wrinkles gone, but they were also able to take care of a few other little flaws in my face. I don’t think I look that different,just more refreshed. I notice myself looking in the mirror more often – because I’m happy. I am very happy with the result.




About this Brand

Our skin is remarkable, protecting our bodies from the outside world and repairing itself every day. However, with age, lifestyle and environmental factors, the condition of our skin deteriorates ...

Naturally Restylane

Naturally Restylane

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